Dietary omega-6 and omega-3 fatty acids and prostate cancer - letter.
نویسندگان
چکیده
Recently, Aronson and colleagues (1) reported that men withprostate cancer receiving approximately 5 g/d of fishoil combined with a low-fat diet (15% kcal from fat) for 4 to 6 weeks before prostatectomy had 32% lower tumor ki67 staining compared with men consuming a Western diet (45%kcal from fat). This study is of interest because thedata suggest that dietary modification can greatly reduce tumor proliferation rates. This article also included results of an in vitro bioassay where sera from subjects preand postintervention was used to culture 22RV1 prostate cancer cells and confirmed these findings. This in vitro bioassay has been reported previously byAronson and colleagues (2, 3) aswell as others (4) to provide evidence of chemoprevention. The in vitro bioassay is attractive, given its simplicity and potential for testing how in vivo changes associated with interventions affect cancer cell proliferation. However, to our knowledge, no study has reported the correlations between data from the in vitro bioassay and in vivo cell proliferation from the same individuals. This study provides a platform and opportunity to test the correlation between these 2 assays and determine whether the in vitro bioassay provides a similar depiction of the in vivo environment. Such data would serve as a substantive contribution to the literature, and we hope that the authors will consider publishing such findings.
منابع مشابه
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.
Although a causal role of genetic alterations in human cancer is well established, it is still unclear whether dietary fat can modulate cancer risk in a predisposed population. Epidemiological studies suggest that diets rich in omega-3 polyunsaturated fatty acids reduce cancer incidence. To determine the influence of fatty acids on prostate cancer risk in animals with a defined genetic lesion, ...
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ورودعنوان ژورنال:
- Cancer prevention research
دوره 5 5 شماره
صفحات -
تاریخ انتشار 2012